IELSG42

IELSG42An international phase II trial assessing tolerability and efficacy of sequential Methotrexate-Aracytin-based combination and R-ICE combination, followed by high-dose chemotherapy supported by autologous stem cell transplant, in patients with systemic B-cell lymphoma with central nervous system involvement at diagnosis or relapse (MARIETTA regimen)
Participants required:76 (enrolment completed)
Investigator responsible(s):A. Ferreri, E. Zucca, K. Cwynarski, G. Illerhaus, A. López-Guillermo, T. Siegal/O. Bairey, J. Bromberg
Objective(s):To evaluate the efficacy and feasibility of a new sequential combination of HD-MTX-AraC-based chemoimmunotherapy, followed by R-ICE regimen, and by high-dose chemotherapy supported by ASCT.

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